OFF-X Safety Assistant

The OFF-X MCP brings Clarivate’s trusted OFF-X Translational Safety Intelligence directly into Claude, enabling natural language questions about drug and target safety. Users can quickly explore safety profiles, assess translational risks, investigate preclinical and clinical safety findings, evaluate class effects, compare drugs and targets, and access safety evidence from scientific publications, conferences, clinical trials registries, regulatory documents and company communications, all grounded in curated OFF-X content.

You can use OFF-X Safety Intelligence to:

Explore Drug and Target Toxicity: “What are the main organ toxicities of IRAK4 inhibitors?”

Surface Safety Insights: “List dose-limiting toxicities, including links to original sources reported in Phase I trials with bcl-2 inhibitors”

Assess Potential Class Effects: “Is lipase increase a class effect of GLP-1 receptor agonists?”

Evaluate Potential Safety Signals: “Has acute kidney injury been reported with orlistat?”

Understand Translational Risk: “What preclinical safety findings for IRAK4 have also been observed clinically?”